C2orf61

Entrez Summary: N/A
UniProt Summary: Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5- methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). {ECO:0000250|UniProtKB:Q9DAG5}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA demethylation of male pronucleus
chromatin reprogramming in the zygote
germinal vesicle
C-5 methylation of cytosine
positive regulation of DNA demethylation
DNA methylation on cytosine
male pronucleus
regulation of DNA demethylation
changes to DNA methylation involved in embryo development
DNA methylation involved in embryo development
female pronucleus
DNA methylation
DNA alkylation
DNA methylation or demethylation
DNA modification
histone binding
positive regulation of DNA metabolic process
macromolecule methylation
methylation
regulation of DNA metabolic process
chromatin binding
chromatin organization
DNA metabolic process
embryo development
chromosome organization
positive regulation of nucleobase-containing compound metabolic process