C6orf106

Gene Information

Official Symbol: ILRUN
Official Name: inflammation and lipid regulator with UBA-like and NBR1-like domains
Aliases and Previous Symbols: N/A
Entrez ID: 64771
UniProt: Q9H6K1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-1.97
TRAIL 5ng/ml R00 exp35	-1.9
Docosahexaenoic-acid 50μM R07 exp356	-1.89
Bleomycin 5μM R08 exp459	1.75
UM131593 0.2μM R03 exp106	1.8
UM0131023 0.05μM R05 exp248	2.11
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.34

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16169
Expression level (log2 read counts): 5.8

Expression Distribution

negative regulation of defense response to virus
phagophore assembly site
negative regulation of protein localization to nucleus
negative regulation of type I interferon production
negative regulation of DNA binding
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
autophagosome
regulation of defense response to virus
ubiquitin binding
negative regulation of response to biotic stimulus
negative regulation of cellular protein localization
regulation of protein localization to nucleus
negative regulation of immune effector process
regulation of DNA binding
regulation of type I interferon production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
macroautophagy
negative regulation of binding
negative regulation of defense response
negative regulation of multi-organism process
autophagy
process utilizing autophagic mechanism
negative regulation of cytokine production
negative regulation of response to external stimulus
regulation of binding
negative regulation of immune system process
regulation of immune effector process
regulation of response to biotic stimulus
regulation of cellular protein localization
regulation of cytokine production
regulation of defense response
innate immune response
regulation of multi-organism process
regulation of cellular localization
defense response to other organism
regulation of protein localization
regulation of response to external stimulus
negative regulation of molecular function