CATSPER3

Entrez Summary: N/A
UniProt Summary: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-1.88
MK-1775 0.32μM R02 exp75	-1.79
S-DABN 8μM R03 exp112	1.73
Hypoxia 5%O2 R04 exp191	1.75
Demecolcine 0.03μM R05 exp228	1.75
Arsenic trioxide 60μM R08 exp449	1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78
UM0131023 0.05μM R05 exp248	1.91
RO-3306 3 to 4μM on day4 R04 exp165	1.95
IU1-C 25μM R04 exp183	1.97
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.19
TNF-alpha 44ng/ml R08 exp533	2.2
CyclicAMP 200μM R08 exp475	2.47

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PKD channel
Ion trans

CatSper complex
sperm capacitation
voltage-gated calcium channel activity
response to progesterone
sperm-egg recognition
cell-cell recognition
sperm motility
flagellated sperm motility
acrosomal vesicle
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
single fertilization
spermatid development
sodium ion transport
spermatid differentiation
cell maturation
fertilization
response to ketone
calcium ion transmembrane transport
cell recognition
developmental maturation
calcium ion transport
germ cell development
divalent metal ion transport
divalent inorganic cation transport
response to steroid hormone
cellular process involved in reproduction in multicellular organism
monovalent inorganic cation transport
regulation of ion transmembrane transport
spermatogenesis
inorganic cation transmembrane transport
regulation of transmembrane transport
male gamete generation
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
developmental process involved in reproduction
gamete generation
regulation of ion transport