CCR3

Entrez Summary: N/A
UniProt Summary: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Latrunculin-B 10μM R07 exp374	-1.94
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.78

7tm 1
7TM GPCR Srsx

chemokine receptor activity
C-C chemokine receptor activity
C-C chemokine binding
chemokine binding
cellular defense response
chemokine-mediated signaling pathway
cellular response to chemokine
response to chemokine
positive regulation of endothelial cell proliferation
regulation of endothelial cell proliferation
calcium-mediated signaling
positive regulation of angiogenesis
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell chemotaxis
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of angiogenesis
regulation of vasculature development
regulation of cytosolic calcium ion concentration
regulation of epithelial cell proliferation
second-messenger-mediated signaling
external side of plasma membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
chemotaxis
taxis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cytokine-mediated signaling pathway
viral process
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis