COPS2

Entrez Summary: N/A
UniProt Summary: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.4μM R08 exp440	-1.95
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.84
BVD-523 15μM R02 exp67	-1.84
GSK-J4 1.5μM R08 exp441	-1.77
TIC10 10μM R08 exp532	-1.77
ML-792 0.2μM R08 exp505	-1.74
Artemisinin 50μM R08 exp450	-1.72
Oligomycin-A 20μM R00 exp26	1.84
Rotenone 2μM R00 exp33	1.84
Etoposide 1μM R00 exp19	1.95
GSK461364A 0.005μM R03 exp125	2.01
MLN-4924 0.2μM R00 exp21	6.08

Global Fraction of Cell Lines Where Essential: 79/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	1/26
breast	4/33
central nervous system	8/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	2/20
lung	10/75
lymphocyte	1/16
ovary	4/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	5/29
uterus	1/5

Expression Distribution

Gene	Correlation
COPS4	0.557
COPS7B	0.516

PCI Csn8
PCI

protein deneddylation
inner cell mass cell proliferation
blastocyst growth
nucleotide-excision repair, DNA damage recognition
COP9 signalosome
skeletal muscle cell differentiation
transcription-coupled nucleotide-excision repair
blastocyst development
nucleotide-excision repair
skeletal muscle tissue development
skeletal muscle organ development
transcription corepressor activity
striated muscle tissue development
muscle organ development
muscle tissue development
protein modification by small protein removal
post-translational protein modification
in utero embryonic development
developmental growth
growth
muscle structure development
transcription by RNA polymerase II
DNA repair
cell population proliferation
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of transcription by RNA polymerase II
protein phosphorylation
embryo development
protein modification by small protein conjugation or removal
neuron differentiation
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process