CRHR2

Entrez Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	-1.88
HMS-I2 10μM R06 exp288	-1.79
CR131-b 0.005μM R08 exp474	-1.72
DABN racemic mixture R03 exp93	1.72
Dimethyloxaloylglycine 100μM R05 exp229	2.1
Nocodazole 0.2μM R00 exp24	2.33
Nocodazole 0.1μM R03 exp94	2.35

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 2
HRM

corticotropin-releasing hormone receptor activity
corticotrophin-releasing factor receptor activity
cellular response to corticotropin-releasing hormone stimulus
response to corticotropin-releasing hormone
peptide hormone binding
long-term synaptic potentiation
axon terminus
positive regulation of synaptic transmission
hormone-mediated signaling pathway
regulation of synaptic plasticity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cellular response to peptide hormone stimulus
axon
cellular response to peptide
response to peptide hormone
dendrite
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
response to peptide
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
response to hormone
response to organonitrogen compound
cellular response to oxygen-containing compound
response to nitrogen compound
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound
positive regulation of cell communication
positive regulation of signaling