CXCL6

Entrez Summary: N/A
UniProt Summary: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269|PubMed:18443119, ECO:0000269|PubMed:8399143, ECO:0000269|PubMed:8423327, ECO:0000269|PubMed:9057843}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of neutrophil mediated killing of gram-negative bacterium
regulation of neutrophil mediated killing of bacterium
regulation of neutrophil mediated killing of symbiont cell
regulation of neutrophil mediated cytotoxicity
regulation of killing of cells of other organism
regulation of defense response to bacterium
chemokine activity
regulation of myeloid leukocyte mediated immunity
antimicrobial humoral immune response mediated by antimicrobial peptide
leukocyte homeostasis
regulation of leukocyte mediated cytotoxicity
regulation of chemokine production
chemokine-mediated signaling pathway
neutrophil chemotaxis
granulocyte chemotaxis
cellular response to chemokine
response to chemokine
neutrophil migration
granulocyte migration
regulation of cell killing
antimicrobial humoral response
myeloid leukocyte migration
leukocyte chemotaxis
heparin binding
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
homeostasis of number of cells
regulation of leukocyte mediated immunity
cell chemotaxis
cellular response to biotic stimulus
regulation of symbiosis, encompassing mutualism through parasitism
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
humoral immune response
leukocyte migration
regulation of immune effector process
inflammatory response
neutrophil activation
granulocyte activation