CYP39A1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product. {ECO:0000269|PubMed:10748047}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R02 exp65	-1.88
Etoposide 0.1μM R05 exp198	1.71
Nicotinamide Riboside 100μM R03 exp139	1.86
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

steroid 7-alpha-hydroxylase activity
oxysterol 7-alpha-hydroxylase activity
bile acid catabolic process
cholesterol catabolic process
sterol catabolic process
bile acid biosynthetic process
steroid catabolic process
bile acid metabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
cholesterol homeostasis
sterol homeostasis
digestion
monocarboxylic acid catabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
lipid homeostasis
sterol metabolic process
heme binding
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
steroid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
endoplasmic reticulum membrane
oxidation-reduction process