EPM2AIP1

Gene Information

Official Symbol: EPM2AIP1
Official Name: EPM2A interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9852
UniProt: Q7L775
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The EPM2A gene, which encodes laforin, is mutated in an autosomal recessive form of adolescent progressive myoclonus epilepsy. The protein encoded by this gene binds to laforin, but its function is not known. This gene is intronless. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16445
Expression level (log2 read counts): 7.12

Expression Distribution

Screen	Score
HMS-I2 10μM R06 exp288	-1.81
A-196 10μM R03 exp114	1.82
Monensin 0.3μM R08 exp507	1.87
Ibrutinib 10μM R08 exp442	1.95

cytoplasmic side of endoplasmic reticulum membrane
positive regulation of glycogen (starch) synthase activity
regulation of glycogen (starch) synthase activity
positive regulation of glycogen biosynthetic process
positive regulation of glycogen metabolic process
regulation of glycogen biosynthetic process
regulation of glucan biosynthetic process
regulation of glycogen metabolic process
regulation of polysaccharide biosynthetic process
positive regulation of glucose metabolic process
regulation of polysaccharide metabolic process
positive regulation of cellular carbohydrate metabolic process
positive regulation of carbohydrate metabolic process
regulation of carbohydrate biosynthetic process
regulation of glucose metabolic process
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
regulation of generation of precursor metabolites and energy
regulation of carbohydrate metabolic process
response to insulin
response to peptide hormone
regulation of small molecule metabolic process
response to peptide
positive regulation of transferase activity
response to hormone
regulation of transferase activity
response to organonitrogen compound
identical protein binding
response to nitrogen compound
positive regulation of catalytic activity
response to endogenous stimulus
response to oxygen-containing compound
positive regulation of molecular function
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process