FCF1

Entrez Summary: N/A
UniProt Summary: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB743921 0.001μM R05 exp244	-1.93
All-trans-Retinoic-Acid 8μM R07 exp333	1.72
Lapatinib 5μM R01 exp47	1.75
Wortmannin 0.5μM R00 exp37	1.95
Cycloheximide 0.02μM R00 exp14	1.96
Cyclosporin-A 3μM R07 exp348	2.09

Global Fraction of Cell Lines Where Essential: 656/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/28
bone	22/26
breast	29/33
central nervous system	49/56
cervix	4/4
colorectal	16/17
esophagus	12/13
fibroblast	0/1
gastric	15/16
kidney	18/21
liver	19/20
lung	70/75
lymphocyte	12/16
ovary	25/26
pancreas	22/24
peripheral nervous system	14/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	27/29
uterus	5/5

Expression Distribution

endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage involved in rRNA processing
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
cleavage involved in rRNA processing
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of 5.8S rRNA
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosomal small subunit biogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression