FGF10

Gene Information

Official Symbol: FGF10
Official Name: fibroblast growth factor 10
Aliases and Previous Symbols: N/A
Entrez ID: 2255
UniProt: O15520
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.08
iCRT14 30μM R08 exp492	-1.97
Lenalidomide 20μM R07 exp375	-1.81
Nocodazole 0.2μM R00 exp24	-1.8
BML-284 0.09μM R08 exp460	-1.72
Nutlin-3A 1.6μM R06 exp294	-1.72
EPZ-5676 30μM R05 exp233	-1.71
VER-155008 3.9μM R06 exp301	1.73
HMS-I2 5μM R06 exp287	2

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8863
Expression level (log2 read counts): -2.43

Expression Distribution

semicircular canal fusion
lung proximal/distal axis specification
submandibular salivary gland formation
bronchiole morphogenesis
lung pattern specification process
positive regulation of hair follicle cell proliferation
mesenchymal-epithelial cell signaling involved in lung development
urothelial cell proliferation
positive regulation of urothelial cell proliferation
regulation of hair follicle cell proliferation
regulation of urothelial cell proliferation
cell-cell signaling involved in lung development
semicircular canal formation
branch elongation involved in salivary gland morphogenesis
mammary gland bud formation
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
tear secretion
mesenchymal cell differentiation involved in lung development
positive regulation of white fat cell proliferation
secretion by lung epithelial cell involved in lung growth
mammary gland bud morphogenesis
proximal/distal axis specification
type 2 fibroblast growth factor receptor binding
bud outgrowth involved in lung branching
embryonic genitalia morphogenesis
female genitalia morphogenesis
mammary gland specification
regulation of white fat cell proliferation
bronchiole development
Harderian gland development
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
male genitalia morphogenesis
positive regulation of fat cell proliferation
male anatomical structure morphogenesis
prostatic bud formation
type II pneumocyte differentiation
epithelial cell proliferation involved in salivary gland morphogenesis
lung growth
mammary gland formation
regulation of saliva secretion