GDF10

Gene Information

Official Symbol: GDF10
Official Name: growth differentiation factor 10
Aliases and Previous Symbols: N/A
Entrez ID: 2662
UniProt: P55107
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016].
UniProt Summary: Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. {ECO:0000250|UniProtKB:P97737}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16023
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
Monensin 0.3μM R08 exp507	-1.75
KU-0063794 3.8μM R02 exp71	1.77
IL-3 9ng/ml R08 exp493	1.82

transforming growth factor beta receptor binding
negative regulation of osteoblast differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of ossification
transforming growth factor beta receptor signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
fat cell differentiation
regulation of osteoblast differentiation
osteoblast differentiation
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
growth factor activity
cytokine activity
regulation of ossification
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ossification
collagen-containing extracellular matrix
skeletal system development
cellular response to growth factor stimulus
response to growth factor
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
negative regulation of developmental process
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
negative regulation of multicellular organismal process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation
response to endogenous stimulus
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
extracellular space