GNG2

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adenylate cyclase-activating dopamine receptor signaling pathway
G-protein beta/gamma-subunit complex
cellular response to prostaglandin E stimulus
G-protein beta-subunit binding
cellular response to prostaglandin stimulus
response to prostaglandin E
response to prostaglandin
heterotrimeric G-protein complex
dopamine receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
cellular response to fatty acid
cellular response to alcohol
response to fatty acid
cellular response to dopamine
response to dopamine
cellular response to ketone
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cellular response to ammonium ion
non-canonical Wnt signaling pathway
platelet activation
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
response to ammonium ion
response to ketone
cellular response to acid chemical
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
protein folding
response to alcohol
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
blood coagulation
coagulation
hemostasis
GTPase activity
second-messenger-mediated signaling
response to acid chemical