HK3

Entrez Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hexokinase 2
Hexokinase 1

hexokinase activity
mannokinase activity
glucokinase activity
fructokinase activity
glucose binding
glucose 6-phosphate metabolic process
carbohydrate phosphorylation
canonical glycolysis
NADH regeneration
glucose catabolic process to pyruvate
glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate
glucose catabolic process
NADH metabolic process
glycolytic process
ATP generation from ADP
NAD metabolic process
ADP metabolic process
hexose catabolic process
nucleoside diphosphate phosphorylation
purine nucleoside diphosphate metabolic process
monosaccharide catabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
cellular glucose homeostasis
glucose metabolic process
secretory granule lumen
carbohydrate catabolic process
ficolin-1-rich granule lumen
hexose metabolic process
cellular carbohydrate metabolic process
glucose homeostasis
carbohydrate homeostasis
monosaccharide metabolic process
ATP metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process