ICK

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Selumetinib 20μM R02 exp81	1.73
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.9

Pkinase
Pkinase Tyr

intraciliary anterograde transport
intraciliary retrograde transport
ciliary base
ciliary tip
intraciliary transport
microtubule-based protein transport
protein transport along microtubule
fibrillar center
ciliary basal body
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
magnesium ion binding
protein kinase activity
protein-containing complex localization
microtubule-based movement
cilium assembly
protein serine/threonine kinase activity
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule-based process
organelle assembly
protein phosphorylation
intracellular protein transport
plasma membrane bounded cell projection organization
cell projection organization
phosphorylation
ATP binding
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
intracellular signal transduction
establishment of localization in cell