IMPA2

Entrez Summary: This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011].
UniProt Summary: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. {ECO:0000269|PubMed:17068342}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-47 25μM R04 exp182	-1.77
WNT3A 44ng/ml R08 exp537	1.83

inositol monophosphate 4-phosphatase activity
inositol biosynthetic process
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol metabolic process
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
polyol catabolic process
phosphatidylinositol phosphorylation
alcohol catabolic process
inositol phosphate metabolic process
polyol biosynthetic process
cellular carbohydrate biosynthetic process
lipid phosphorylation
organic hydroxy compound catabolic process
polyol metabolic process
alcohol biosynthetic process
carbohydrate biosynthetic process
organophosphate catabolic process
phosphatidylinositol metabolic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
lipid modification
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
small molecule biosynthetic process
protein homodimerization activity
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
phosphorylation
small molecule metabolic process
organic substance catabolic process