KCTD15

Entrez Summary: N/A
UniProt Summary: During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain. {ECO:0000250, ECO:0000269|PubMed:23382213}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cadmium 60μM R08 exp462	-2.29
MS023 7μM R03 exp135	-2.23
Lapatinib 5μM R01 exp47	-1.88
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.7
Pomalidomide 20μM R07 exp391	1.77
3-Bromopyruvate 7μM R04 exp175	2.04
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.39

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein homooligomerization
protein complex oligomerization
identical protein binding
protein-containing complex assembly
protein-containing complex subunit organization