KIAA1429

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubacin 1.6μM R07 exp416	-2.16
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.94
Caffeine 2600μM R08 exp463	-1.8
Methotrexate 0.01μM R08 exp501	-1.78
BN82002 4μM R07 exp340	-1.7
NFN1 0.4μM R03 exp99	1.71
GSK626616 14μM R08 exp485	1.77
LB-100 2μM R05 exp210	1.82
AICAR 240μM R03 exp116	1.97
Bisphenol S 100μM R08 exp458	2.1
Metformin 100 to 150μM on day4 R04 exp170	2.24
UM0131023 0.05μM R05 exp248	2.24

Global Fraction of Cell Lines Where Essential: 388/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	15/28
blood	21/28
bone	9/26
breast	16/33
central nervous system	29/56
cervix	1/4
colorectal	14/17
esophagus	5/13
fibroblast	1/1
gastric	8/16
kidney	6/21
liver	11/20
lung	36/75
lymphocyte	9/16
ovary	13/26
pancreas	11/24
peripheral nervous system	10/16
plasma cell	11/15
prostate	0/1
skin	10/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	16/29
uterus	3/5

Expression Distribution

mRNA alternative polyadenylation
RNA N6-methyladenosine methyltransferase complex
mRNA methylation
regulation of mRNA polyadenylation
mRNA modification
regulation of mRNA 3-end processing
RNA methylation
regulation of mRNA processing
RNA modification
macromolecule methylation
nuclear body
methylation
regulation of mRNA metabolic process
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression