LIMK1

Gene Information

Official Symbol: LIMK1
Official Name: LIM domain kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 3984
UniProt: P53667
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16350
Expression level (log2 read counts): 5.09

Expression Distribution

Screen	Score
Apcin 25μM plus proTAME 2μM R04 exp177	-1.78
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.81
WNT3A 44ng/ml R08 exp537	1.9

Pkinase Tyr
LIM
Pkinase
Kdo
PDZ

negative regulation of ubiquitin-protein transferase activity
positive regulation of axon extension
positive regulation of stress fiber assembly
regulation of ubiquitin-protein transferase activity
heat shock protein binding
positive regulation of actin filament bundle assembly
negative regulation of protein ubiquitination
Rho protein signal transduction
regulation of stress fiber assembly
negative regulation of protein modification by small protein conjugation or removal
positive regulation of axonogenesis
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
regulation of axon extension
regulation of extent of cell growth
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
positive regulation of developmental growth
lamellipodium
regulation of cell size
regulation of axonogenesis
positive regulation of supramolecular fiber organization
regulation of protein ubiquitination
positive regulation of cytoskeleton organization
regulation of protein modification by small protein conjugation or removal
protein kinase activity
Fc receptor signaling pathway
Ras protein signal transduction
positive regulation of growth
regulation of actin filament organization
negative regulation of transferase activity
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
small GTPase mediated signal transduction
neuron projection
regulation of developmental growth