LLPH

Entrez Summary: N/A
UniProt Summary: In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission. {ECO:0000250|UniProtKB:Q9D945}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1.5μM R08 exp441	-1.92
TIC10 10μM R08 exp532	-1.84
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.79
Trimetrexate 0.03μM R08 exp535	-1.74
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.71
Dynasore 7μM R08 exp436	-1.7
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.79
TNF-alpha 44ng/ml R08 exp533	1.85
Trametinib 10μM R02 exp83	1.94
Wortmannin 0.5μM R00 exp37	2.13
FBS-Wisent 0.1 R07 exp426	2.28
UM0011500 5μM R05 exp245	2.41

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

basal RNA polymerase II transcription machinery binding
dendrite extension
positive regulation of dendritic spine development
neuron projection extension
positive regulation of dendrite development
regulation of dendritic spine development
developmental cell growth
cell growth
developmental growth involved in morphogenesis
chromosome
regulation of dendrite development
positive regulation of neuron projection development
positive regulation of neuron differentiation
positive regulation of cell projection organization
developmental growth
growth
positive regulation of neurogenesis
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
regulation of neuron projection development
cell part morphogenesis
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
cell morphogenesis
neuron development
regulation of neurogenesis
cellular component morphogenesis
nucleolus
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of cellular component organization