LYN

Gene Information

Official Symbol: LYN
Official Name: LYN proto-oncogene, Src family tyrosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 4067
UniProt: P07948
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
UniProt Summary: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down- regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3- kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr- 72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:7687428}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-2.01
Ibrutinib 1μM R07 exp372	-1.81
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.73
Epigallocatechin gallate 20μM R05 exp230	1.78
Benzoate 10000μM R08 exp455	1.83
Lead acetate 2000μM R08 exp498 no dilution day6	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18357
Expression level (log2 read counts): 6.33

Expression Distribution

SH2
Pkinase Tyr
SH3 1
Pkinase
SH3 2

negative regulation of mast cell proliferation
positive regulation of mast cell proliferation
positive regulation of dendritic cell apoptotic process
Fc receptor mediated inhibitory signaling pathway
histamine production involved in inflammatory response
positive regulation of oligodendrocyte progenitor proliferation
phosphorylation-dependent protein binding
histamine secretion involved in inflammatory response
integrin alpha2-beta1 complex
regulation of mast cell proliferation
histamine secretion by mast cell
postsynaptic specialization, intracellular component
tolerance induction to self antigen
negative regulation of toll-like receptor 2 signaling pathway
glycosphingolipid binding
mitochondrial crista
immune response-inhibiting cell surface receptor signaling pathway
histamine secretion
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
regulation of oligodendrocyte progenitor proliferation
histamine transport
immune response-inhibiting signal transduction
positive regulation of aspartic-type peptidase activity
negative regulation of toll-like receptor 4 signaling pathway
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
regulation of toll-like receptor 2 signaling pathway
response to sterol depletion
regulation of dendritic cell apoptotic process
regulation of aspartic-type peptidase activity
regulation of Fc receptor mediated stimulatory signaling pathway
tolerance induction
growth hormone receptor signaling pathway via JAK-STAT
positive regulation of glial cell proliferation
platelet-derived growth factor receptor binding
negative regulation of B cell proliferation
production of molecular mediator involved in inflammatory response
mast cell activation involved in immune response
mast cell degranulation
regulation of B cell apoptotic process