MTSS1L

Entrez Summary: N/A
UniProt Summary: Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ruffle assembly
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
ruffle organization
actin monomer binding
lamellipodium organization
cortical actin cytoskeleton
Rac GTPase binding
phosphatidylinositol-4,5-bisphosphate binding
plasma membrane organization
ruffle membrane
activation of GTPase activity
lamellipodium
GTPase activator activity
positive regulation of GTPase activity
endomembrane system organization
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of GTPase activity
cellular response to growth factor stimulus
response to growth factor
positive regulation of hydrolase activity
membrane organization
plasma membrane bounded cell projection organization
cell projection organization
cellular response to endogenous stimulus
regulation of hydrolase activity
positive regulation of catalytic activity
response to endogenous stimulus
positive regulation of molecular function