MZB1

Entrez Summary: N/A
UniProt Summary: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250, ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:21688198}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Curcumin 6.5μM R06 exp277	1.71
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.73
FTY720 3μM R08 exp483	1.79

positive regulation of immunoglobulin biosynthetic process
regulation of immunoglobulin biosynthetic process
integrin activation
endoplasmic reticulum chaperone complex
positive regulation of immunoglobulin production
regulation of B cell proliferation
regulation of insulin receptor signaling pathway
regulation of immunoglobulin production
regulation of cellular response to insulin stimulus
positive regulation of production of molecular mediator of immune response
regulation of production of molecular mediator of immune response
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of immune effector process
regulation of leukocyte proliferation
endoplasmic reticulum lumen
regulation of immune effector process
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
positive regulation of cell population proliferation
apoptotic process
programmed cell death
cell death
positive regulation of immune system process
protein-containing complex assembly
regulation of cell population proliferation
regulation of immune system process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
extracellular region
positive regulation of biosynthetic process