NCOA4

Entrez Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
UniProt Summary: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. {ECO:0000269|PubMed:10347167}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.51
Dimethyloxaloylglycine 100μM R05 exp229	-1.89
Cerivastatin 0.15μM R05 exp226	-1.73
Thimerosal 0.85μM R08 exp529	1.85
BML-284 0.09μM R08 exp460	1.89

Global Fraction of Cell Lines Where Essential: 23/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	2/21
liver	1/20
lung	4/75
lymphocyte	0/14
ovary	2/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	2/5

Expression Distribution

autolysosome
protein targeting to lysosome
protein targeting to vacuole
androgen receptor signaling pathway
protein localization to lysosome
androgen receptor binding
establishment of protein localization to vacuole
cellular iron ion homeostasis
protein localization to vacuole
intracellular steroid hormone receptor signaling pathway
iron ion homeostasis
lysosomal transport
cellular transition metal ion homeostasis
steroid hormone mediated signaling pathway
transition metal ion homeostasis
male gonad development
development of primary male sexual characteristics
vacuolar transport
male sex differentiation
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
gonad development
development of primary sexual characteristics
sex differentiation
transcription coactivator activity
response to steroid hormone
protein targeting
reproductive structure development
reproductive system development
establishment of protein localization to organelle
cellular response to lipid
cellular response to organic cyclic compound
cellular metal ion homeostasis
cellular response to hormone stimulus
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
developmental process involved in reproduction
cation homeostasis