NFAM1

Entrez Summary: N/A
UniProt Summary: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
L-74142 5μM R03 exp131	1.75
Ribavirin 10μM R01 exp52	1.95

positive regulation of B cell receptor signaling pathway
positive regulation of antigen receptor-mediated signaling pathway
regulation of B cell receptor signaling pathway
regulation of B cell differentiation
azurophil granule membrane
regulation of antigen receptor-mediated signaling pathway
B cell differentiation
transmembrane signaling receptor activity
B cell activation
regulation of lymphocyte differentiation
regulation of B cell activation
lymphocyte differentiation
positive regulation of DNA-binding transcription factor activity
regulation of leukocyte differentiation
leukocyte differentiation
lymphocyte activation
regulation of DNA-binding transcription factor activity
positive regulation of cytokine production
regulation of hemopoiesis
neutrophil degranulation
neutrophil activation involved in immune response
inflammatory response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
regulation of lymphocyte activation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
hemopoiesis
myeloid leukocyte activation
regulation of leukocyte activation
hematopoietic or lymphoid organ development
leukocyte activation involved in immune response
cell activation involved in immune response
regulation of cell activation
immune system development
regulation of cytokine production
regulated exocytosis
leukocyte mediated immunity