NOL3
Gene Information
- Official Symbol: NOL3
- Official Name: nucleolar protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 8996
- UniProt: O60936
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
- UniProt Summary: Isoform 1: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.
Pfam Domains GO Terms
Pfam Domains
| CARD |
GO Terms
| response to injury involved in regulation of muscle adaptation |
| negative regulation of muscle atrophy |
| negative regulation of mitochondrial membrane permeability involved in apoptotic process |
| death effector domain binding |
| regulation of muscle atrophy |
| cardiac muscle cell apoptotic process |
| negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| striated muscle cell apoptotic process |
| regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| muscle cell apoptotic process |
| negative regulation of mitochondrial membrane permeability |
| negative regulation of cellular response to hypoxia |
| inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of membrane permeability |
| release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| release of sequestered calcium ion into cytosol by endoplasmic reticulum |
| negative regulation of muscle adaptation |
| caspase binding |
| zymogen inhibition |
| inhibition of cysteine-type endopeptidase activity |
| regulation of cellular response to hypoxia |
| sarcoplasmic reticulum calcium ion transport |
| death receptor binding |
| response to stimulus involved in regulation of muscle adaptation |
| negative regulation of necrotic cell death |
| negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| negative regulation of release of cytochrome c from mitochondria |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of cardiac muscle cell apoptotic process |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| negative regulation of striated muscle cell apoptotic process |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| regulation of necrotic cell death |
| mRNA splice site selection |
| blood vessel remodeling |
| negative regulation of protein processing |
| negative regulation of protein maturation |
| regulation of cardiac muscle cell apoptotic process |
| negative regulation of muscle cell apoptotic process |
| regulation of striated muscle cell apoptotic process |
| sarcoplasmic reticulum |
| negative regulation of cellular response to oxidative stress |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of response to oxidative stress |
| regulation of release of cytochrome c from mitochondria |
| response to ischemia |
| negative regulation of mitochondrion organization |
| release of sequestered calcium ion into cytosol |
| spliceosomal complex assembly |
| negative regulation of sequestering of calcium ion |
| regulation of tumor necrosis factor-mediated signaling pathway |
| apoptotic mitochondrial changes |
| negative regulation of cytokine-mediated signaling pathway |
| regulation of oxidative stress-induced cell death |
| negative regulation of response to cytokine stimulus |
| regulation of protein processing |
| calcium ion transmembrane import into cytosol |
| regulation of protein maturation |
| regulation of muscle cell apoptotic process |
| regulation of mitochondrial membrane permeability |
| calcium ion transport into cytosol |
| regulation of cellular response to oxidative stress |
| regulation of membrane permeability |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of response to oxidative stress |
| regulation of muscle adaptation |
| cytosolic calcium ion transport |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| tissue remodeling |
| negative regulation of extrinsic apoptotic signaling pathway |
| regulation of NIK/NF-kappaB signaling |
| regulation of sequestering of calcium ion |
| mitochondrial membrane organization |
| intrinsic apoptotic signaling pathway |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| regulation of mitochondrion organization |
| calcium ion transmembrane transport |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| negative regulation of apoptotic signaling pathway |
| ribonucleoprotein complex assembly |
| regulation of muscle system process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| ribonucleoprotein complex subunit organization |
| calcium ion transport |
| negative regulation of peptidase activity |
| positive regulation of cytosolic calcium ion concentration |
| apoptotic signaling pathway |
| divalent metal ion transport |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| response to hypoxia |
| negative regulation of proteolysis |
| response to decreased oxygen levels |
| negative regulation of organelle organization |
| response to oxygen levels |
| RNA splicing |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| cellular calcium ion homeostasis |
| mitochondrion organization |
| regulation of peptidase activity |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| ribonucleoprotein complex biogenesis |
| cellular divalent inorganic cation homeostasis |
| mRNA processing |
| divalent inorganic cation homeostasis |
| negative regulation of intracellular signal transduction |
| protein complex oligomerization |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| response to wounding |
| regulation of system process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| mRNA metabolic process |
| negative regulation of cellular component organization |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| ion homeostasis |
| negative regulation of catalytic activity |
| cation transport |
| cellular protein-containing complex assembly |
| membrane organization |
| nucleolus |
| RNA processing |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| apoptotic process |
| ion transmembrane transport |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| identical protein binding |
| cell death |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| negative regulation of molecular function |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| transmembrane transport |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| RNA binding |
| regulation of response to stress |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| homeostatic process |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| negative regulation of gene expression |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| FBS-Wisent 0.1 R07 exp426 | -1.99 |
| IU1-47 25μM R04 exp182 | -1.93 |
| LJH685 5μM R02 exp73 | -1.85 |
| Tunicamycin 0.04μM R07 exp418 | -1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3903
- Expression level (log2 read counts): 2.81
Expression Distribution
NOL3 Expression in NALM6 Cells: 2.81
