NPHS2

Entrez Summary: This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 2μM R03 exp121	-1.89
Hydroxyurea 100μM R07 exp329	1.77
Disulfiram 4.3μM R06 exp281	1.82
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.93
HMS-I2 10μM R06 exp288	1.96
2-Methoxyestradiol 0.2μM R01 exp40	2.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

metanephric glomerular visceral epithelial cell differentiation
metanephric glomerular epithelium development
metanephric glomerular epithelial cell development
metanephric glomerular visceral epithelial cell development
metanephric glomerular epithelial cell differentiation
intrinsic component of the cytoplasmic side of the plasma membrane
glomerular visceral epithelial cell development
slit diaphragm
metanephric glomerulus development
glomerular epithelial cell development
glomerular visceral epithelial cell differentiation
renal filtration cell differentiation
metanephric nephron epithelium development
glomerular epithelial cell differentiation
cell differentiation involved in metanephros development
glomerular epithelium development
metanephric epithelium development
epithelial cell differentiation involved in kidney development
metanephric nephron development
cell differentiation involved in kidney development
excretion
glomerulus development
actin cytoskeleton reorganization
metanephros development
nephron epithelium development
nephron development
kidney epithelium development
cell-cell junction
epithelial cell development
membrane raft
kidney development
renal system development
urogenital system development
actin cytoskeleton organization
actin filament-based process
protein-containing complex
epithelial cell differentiation
endoplasmic reticulum
cytoskeleton organization
epithelium development