PLAGL2

Gene Information

Official Symbol: PLAGL2
Official Name: PLAG1 like zinc finger 2
Aliases and Previous Symbols: N/A
Entrez ID: 5326
UniProt: Q9UPG8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Shows weak transcriptional activatory activity.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Artemisinin 50μM R08 exp450	1.7
Latrunculin-B 10μM R07 exp374	1.73
iCRT14 30μM R08 exp492	1.79
AICAR 240μM R03 exp116	1.8
Pyridostatin 4μM R05 exp240	2.08

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6654
Expression level (log2 read counts): 5.77

Expression Distribution

chylomicron assembly
plasma lipoprotein particle assembly
protein-lipid complex assembly
plasma lipoprotein particle organization
protein-lipid complex subunit organization
positive regulation of intrinsic apoptotic signaling pathway
regulation of plasma lipoprotein particle levels
post-embryonic development
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
extracellular structure organization
regulation of apoptotic signaling pathway
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription, DNA-templated
nucleic acid-templated transcription
positive regulation of apoptotic process
positive regulation of programmed cell death
RNA biosynthetic process
DNA-binding transcription factor activity
positive regulation of cell death
positive regulation of intracellular signal transduction
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
lipid metabolic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
regulation of apoptotic process
positive regulation of transcription, DNA-templated
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
RNA metabolic process
regulation of cell death
cellular macromolecule biosynthetic process