POLR2C

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.2μM R00 exp24	-2.14
QNZ 0.01μM R05 exp241	-1.95
Torin1 0.08μM R02 exp82	-1.91
AICAR 240μM R05 exp211	-1.88
SGC0946 7μM R03 exp151	-1.82
Pimelic-diphenylamide-106 5μM R00 exp28	-1.79
Dimethyloxaloylglycine 100μM R05 exp229	-1.76
5-Fluorouracil 20μM R00 exp2	-1.71
Actinomycin-D 0.001μM R00 exp3	-1.71
QNZ 0.01μM R08 exp439	1.73
Lapatinib 5μM R01 exp47	1.76
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.77
UM131593 0.1μM R01 exp58	1.79
Zebularine 20μM R07 exp423	2.01
Glyphosate 1000μM R06 exp283	2.11
CVT-10216 0.1μM R06 exp278	2.32
Methotrexate 0.01μM R08 exp501	2.76

Global Fraction of Cell Lines Where Essential: 721/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	20/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
POLR2J3	0.459
PRIM1	0.448

RNA pol L
RNA pol A bac

RNA polymerase II activity
RNA polymerase II, core complex
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
positive regulation of viral transcription
regulation of viral transcription
somatic stem cell population maintenance
snRNA transcription by RNA polymerase II
snRNA transcription
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
fibroblast growth factor receptor signaling pathway
regulation of gene silencing by miRNA
regulation of posttranscriptional gene silencing
regulation of gene silencing by RNA
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
nucleotide-excision repair
response to fibroblast growth factor
regulation of gene silencing
stem cell population maintenance
maintenance of cell number
microtubule cytoskeleton
protein dimerization activity
transcription initiation from RNA polymerase II promoter
regulation of viral process
DNA-templated transcription, initiation
regulation of symbiosis, encompassing mutualism through parasitism
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
cellular response to growth factor stimulus
DNA repair
positive regulation of multi-organism process