PSIP1

Entrez Summary: N/A
UniProt Summary: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PWWP
LEDGF

supercoiled DNA binding
mRNA 5-splice site recognition
establishment of integrated proviral latency
establishment of viral latency
viral latency
transcriptionally active chromatin
mRNA splice site selection
mRNA cis splicing, via spliceosome
spliceosomal complex assembly
response to heat
response to temperature stimulus
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
response to oxidative stress
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
viral process
symbiotic process
interspecies interaction between organisms
cellular protein-containing complex assembly
RNA processing
response to abiotic stimulus
RNA binding
intracellular transport
protein-containing complex assembly
RNA metabolic process
establishment of localization in cell
protein-containing complex subunit organization
gene expression