RAB21

Entrez Summary: N/A
UniProt Summary: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
KIAA0196	0.457
CCDC53	0.418

cytoplasmic side of early endosome membrane
positive regulation of early endosome to late endosome transport
positive regulation of cytoplasmic transport
regulation of early endosome to late endosome transport
regulation of cytoplasmic transport
vesicle membrane
positive regulation of dendrite morphogenesis
anterograde axonal transport
positive regulation of receptor-mediated endocytosis
cytoplasmic side of plasma membrane
cleavage furrow
axonal transport
axon cytoplasm
axo-dendritic transport
Rab protein signal transduction
positive regulation of dendrite development
GDP binding
regulation of dendrite morphogenesis
Golgi cisterna membrane
regulation of axon extension
regulation of receptor-mediated endocytosis
positive regulation of endocytosis
regulation of extent of cell growth
cytoplasmic vesicle membrane
regulation of dendrite development
early endosome membrane
positive regulation of cell morphogenesis involved in differentiation
transport along microtubule
trans-Golgi network
cytoskeleton-dependent intracellular transport
regulation of cell size
microtubule-based transport
regulation of axonogenesis
regulation of endocytosis
positive regulation of intracellular transport
regulation of exocytosis
Ras protein signal transduction
early endosome
synapse
endosome