RAMP3
Gene Information
- Official Symbol: RAMP3
- Official Name: receptor activity modifying protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10268
- UniProt: O60896
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.
Pfam Domains GO Terms
Pfam Domains
| RAMP |
GO Terms
| positive regulation of calcium ion import across plasma membrane |
| amylin receptor complex 3 |
| cross-receptor inhibition within G protein-coupled receptor heterodimer |
| adrenomedullin receptor activity |
| adrenomedullin receptor complex |
| regulation of calcium ion import across plasma membrane |
| amylin receptor activity |
| adrenomedullin receptor signaling pathway |
| amylin receptor signaling pathway |
| calcitonin family receptor signaling pathway |
| G protein-coupled receptor signaling pathway involved in heart process |
| positive regulation of protein kinase A signaling |
| positive regulation of receptor recycling |
| positive regulation of calcium ion import |
| regulation of protein kinase A signaling |
| regulation of receptor recycling |
| coreceptor activity |
| cellular response to estradiol stimulus |
| regulation of calcium ion import |
| response to amyloid-beta |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of protein localization to plasma membrane |
| negative regulation of signaling receptor activity |
| receptor internalization |
| positive regulation of protein localization to cell periphery |
| positive regulation of calcium ion transmembrane transport |
| cell |
| amyloid-beta binding |
| regulation of protein localization to plasma membrane |
| regulation of calcium ion transport into cytosol |
| heart process |
| positive regulation of peptidyl-serine phosphorylation |
| receptor metabolic process |
| regulation of protein localization to cell periphery |
| positive regulation of calcium ion transport |
| positive regulation of protein localization to membrane |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| response to estradiol |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of cation transmembrane transport |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of calcium ion transmembrane transport |
| cAMP-mediated signaling |
| positive regulation of ion transmembrane transport |
| positive regulation of protein kinase B signaling |
| cyclic-nucleotide-mediated signaling |
| regulation of signaling receptor activity |
| protein localization to plasma membrane |
| regulation of protein localization to membrane |
| positive regulation of transmembrane transport |
| receptor complex |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of protein kinase B signaling |
| protein localization to cell periphery |
| receptor-mediated endocytosis |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| calcium ion transport |
| lysosome |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| divalent inorganic cation transport |
| angiogenesis |
| positive regulation of cellular protein localization |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| regulation of metal ion transport |
| circulatory system process |
| blood vessel morphogenesis |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| blood vessel development |
| divalent inorganic cation homeostasis |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| endocytosis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| cellular response to hormone stimulus |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| tube morphogenesis |
| import into cell |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| cation transport |
| tube development |
| response to lipid |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| positive regulation of transport |
| intracellular protein transport |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| ion transport |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| vesicle-mediated transport |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.2μM R00 exp24 | 1.83 |
| R-DABN 8μM R03 exp111 | 1.83 |
| Nocodazole 0.2μM R02 exp64 | 1.91 |
| SB743921 0.001μM R05 exp244 | 2.06 |
| Nocodazole 0.1μM R03 exp94 | 2.44 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4717
- Expression level (log2 read counts): -7.68
Expression Distribution
RAMP3 Expression in NALM6 Cells: -7.68
