RBM6 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: RBM6
Official Name: RNA binding motif protein 6
Aliases and Previous Symbols: N/A
Entrez ID: 10180
UniProt: P78332
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Specifically binds poly(G) RNA homopolymers in vitro.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.56
Adefovir 20μM R07 exp332	-2.36
I-BRD9 4μM R07 exp365	1.7
Demecolcine 0.03μM R05 exp228	1.71
BML-284 0.09μM R08 exp460	1.73
LLY-283 2.6μM R06 exp290	1.73
Olaparib 4μM R08 exp512	1.73
CyclicAMP 200μM R08 exp475	1.76
GSK626616 14μM R08 exp485	2.01
Trimetrexate 0.03μM R08 exp535	2.19
GSK-J4 1.5μM R08 exp441	2.22
Methotrexate 0.01μM R08 exp501	2.43
TRAIL 5ng/ml R00 exp35	2.76
TRAIL 50ng/ml R00 exp36	3.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9817
Expression level (log2 read counts): 7.02

Expression Distribution

Last modified: 2025/12/10 20:19
by 127.0.0.1