RBPMS2

Entrez Summary: N/A
UniProt Summary: Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation. {ECO:0000250|UniProtKB:Q9W6I1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of smooth muscle cell differentiation
embryonic digestive tract morphogenesis
regulation of smooth muscle cell differentiation
embryonic digestive tract development
digestive tract morphogenesis
negative regulation of BMP signaling pathway
negative regulation of muscle cell differentiation
positive regulation of smooth muscle cell proliferation
regulation of BMP signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
digestive tract development
regulation of smooth muscle cell proliferation
digestive system development
negative regulation of cellular response to growth factor stimulus
regulation of muscle cell differentiation
mRNA binding
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
embryonic organ morphogenesis
embryonic organ development
embryonic morphogenesis
tube morphogenesis
negative regulation of cell differentiation
tube development
protein homodimerization activity
positive regulation of cell population proliferation
negative regulation of developmental process
animal organ morphogenesis
embryo development
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of cell population proliferation
negative regulation of response to stimulus
regulation of cell differentiation