REC8

Entrez Summary: N/A
UniProt Summary: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.23
Cerivastatin 0.15μM R05 exp226	-2.14
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.14
Dihydrosphingosine 8μM R08 exp476	-1.78
UM0125461 0.74μM R02 exp84	-1.71
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.76
Bleomycin 5μM R08 exp459	1.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rad21 Rec8
Rad21 Rec8 N

nuclear meiotic cohesin complex
meiotic cohesin complex
condensed nuclear chromosome kinetochore
seminiferous tubule development
lateral element
male germ cell nucleus
synaptonemal complex assembly
oocyte maturation
synaptonemal complex organization
male meiosis I
oocyte development
oocyte differentiation
synapsis
male meiotic nuclear division
sister chromatid cohesion
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
oogenesis
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
meiosis I
meiosis I cell cycle process
female gamete generation
male gonad development
anatomical structure maturation
development of primary male sexual characteristics
sister chromatid segregation
spermatid development
meiotic nuclear division
male sex differentiation
spermatid differentiation
cell maturation
meiotic cell cycle process
fertilization
double-strand break repair
gonad development
development of primary sexual characteristics