RNF214

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Azithromycin 100μM R08 exp452	-2.15
Sucrose 20000μM R06 exp298	-1.79
Aminopterin 0.005μM R07 exp335	1.71
Dynasore 7μM R08 exp436	1.71
Aphidicolin 0.4μM R08 exp440	1.74
Benzoate 20000μM R08 exp456	1.8
AICAR 240μM R05 exp211	1.81
Deferoxamine 11μM R07 exp350	1.86
Staurosporine 0.02μM R08 exp524	1.91
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.92
GSK-J4 1.5μM R08 exp441	1.94
CyclicAMP 200μM R08 exp475	1.97
Olaparib 4μM R08 exp512	1.98
SNS-032 15μM R08 exp443	2.04
Mitomycin-C 0.06μM R08 exp503	2.15
GSK626616 14μM R08 exp485	2.16
Methotrexate 0.01μM R08 exp501	2.27
Hippuristanol 0.12μM R08 exp488	2.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
DOHH	0.423
BAK1	0.402

ubiquitin-protein transferase activity
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal