RNF34

Gene Information

Official Symbol: RNF34
Official Name: ring finger protein 34
Aliases and Previous Symbols: N/A
Entrez ID: 80196
UniProt: Q969K3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.85
PF-06409577 20μM R07 exp389	1.83
Tenofovir 10μM R07 exp405	1.85
THZ531 0.11μM R07 exp409	1.85
Taxol 0.004μM R03 exp103	1.87
Latrunculin-B 10μM R07 exp374	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16938
Expression level (log2 read counts): 5.95

Expression Distribution

regulation of oxygen metabolic process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
cellular response to cold
phosphatidylinositol phosphate binding
negative regulation of execution phase of apoptosis
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of execution phase of apoptosis
response to cold
protein K48-linked ubiquitination
regulation of extrinsic apoptotic signaling pathway via death domain receptors
p53 binding
endomembrane system
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
intracellular receptor signaling pathway
response to temperature stimulus
regulation of signal transduction by p53 class mediator
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ubiquitin protein ligase activity
negative regulation of apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
nuclear body
ubiquitin protein ligase binding
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
negative regulation of proteolysis
regulation of apoptotic signaling pathway
nuclear speck
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
negative regulation of intracellular signal transduction