RPA4

Entrez Summary: This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010].
UniProt Summary: As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19942684, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:20545304}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
YM155 0.001μM R08 exp432	-1.78
Nocodazole 0.02μM R00 exp23	1.9

DNA replication factor A complex
DNA replication initiation
nuclear DNA replication
cell cycle DNA replication
chromosome, telomeric region
site of double-strand break
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
nucleotide-excision repair
G1/S transition of mitotic cell cycle
DNA-dependent DNA replication
cell cycle G1/S phase transition
DNA damage checkpoint
DNA integrity checkpoint
double-strand break repair
cell cycle checkpoint
DNA replication
DNA recombination
mitotic cell cycle phase transition
cell cycle phase transition
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
regulation of cell cycle
cell cycle
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process