RXRB

Gene Information

Official Symbol: RXRB
Official Name: retinoid X receptor beta
Aliases and Previous Symbols: N/A
Entrez ID: 6257
UniProt: P28702
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
UniProt Summary: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). {ECO:0000269|PubMed:1310259}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.15
Rapamycin 10μM R00 exp30	-2.06
CCCP 1μM R00 exp11	-1.89
INK128 0.2μM R02 exp70	-1.85
Oligomycin-A 2μM R00 exp25	-1.82
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.78
SGC2096 2.6μM R03 exp153	-1.76
Selumetinib 20μM R02 exp81	-1.71
Vinorelbine 0.001μM R05 exp249	-1.71
Mubritinib 0.2μM R01 exp48	1.71
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.76
Cannabidiol 20μM R08 exp466	1.84
Rucaparib 6.5μM R08 exp520	2.03
UM0125461 0.74μM R02 exp84	2.46
Olaparib 4μM R08 exp512	2.55
Tubacin 1.6μM R07 exp416	3.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5131
Expression level (log2 read counts): 5.59

Expression Distribution

Hormone recep
zf-C4
Nuc recep-AF1

retinoic acid-responsive element binding
retinoic acid receptor signaling pathway
nuclear receptor activity
steroid hormone receptor activity
RNA polymerase II transcription factor complex
response to retinoic acid
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
DNA-templated transcription, initiation
transcription coactivator activity
RNA polymerase II regulatory region sequence-specific DNA binding
response to steroid hormone
response to acid chemical
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
zinc ion binding
response to lipid
response to hormone
response to organic cyclic compound
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
organic cyclic compound biosynthetic process
response to endogenous stimulus
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process