SEC24A

Gene Information

Official Symbol: SEC24A
Official Name: SEC24 homolog A, COPII coat complex component
Aliases and Previous Symbols: N/A
Entrez ID: 10802
UniProt: O95486
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15633
Expression level (log2 read counts): 5.39

Expression Distribution

Screen	Score
Cerivastatin 0.15μM R05 exp226	-1.84
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.9
Thapsigargin 0.005μM R07 exp407	2.35

Sec23 BS
Gelsolin
Sec23 trunk
zf-Sec23 Sec24
Sec23 helical

regulation of low-density lipoprotein particle receptor biosynthetic process
COPII-coated vesicle cargo loading
COPII vesicle coat
regulation of receptor biosynthetic process
vesicle cargo loading
ER to Golgi transport vesicle membrane
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
cholesterol homeostasis
sterol homeostasis
localization within membrane
vesicle targeting
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
lipid homeostasis
establishment of vesicle localization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
vesicle localization
antigen processing and presentation of peptide antigen
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
positive regulation of protein secretion
positive regulation of peptide secretion
vesicle organization
establishment of organelle localization
Golgi vesicle transport
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion