SEMA3D

Entrez Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016].
UniProt Summary: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
KU-0063794 3.8μM R02 exp71	-1.72
2-Methoxyestradiol 0.2μM R01 exp40	1.7

neuropilin binding
semaphorin receptor binding
negative regulation of axon extension involved in axon guidance
chemorepellent activity
negative regulation of axon guidance
regulation of axon extension involved in axon guidance
semaphorin-plexin signaling pathway
negative regulation of axon extension
regulation of axon guidance
negative chemotaxis
neural crest cell migration
negative regulation of chemotaxis
negative regulation of axonogenesis
neural crest cell development
mesenchymal cell development
stem cell development
neural crest cell differentiation
regulation of axon extension
negative regulation of cell morphogenesis involved in differentiation
negative regulation of developmental growth
regulation of extent of cell growth
negative regulation of neuron projection development
mesenchymal cell differentiation
stem cell differentiation
ameboidal-type cell migration
negative regulation of cell projection organization
regulation of cell size
negative regulation of cell growth
regulation of axonogenesis
regulation of chemotaxis
mesenchyme development
negative regulation of neuron differentiation
negative regulation of growth
axon guidance
neuron projection guidance
negative regulation of neurogenesis
regulation of cell morphogenesis involved in differentiation
negative regulation of cellular component movement
negative regulation of nervous system development
negative regulation of locomotion