SERGEF

Entrez Summary: N/A
UniProt Summary: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ran guanyl-nucleotide exchange factor activity
aggresome
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
negative regulation of secretion
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
intracellular membrane-bounded organelle
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
regulation of protein localization
regulation of transport