SFSWAP

Entrez Summary: N/A
UniProt Summary: Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 78/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	5/28
bone	5/26
breast	4/33
central nervous system	3/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	1/20
lung	8/75
lymphocyte	3/16
ovary	3/26
pancreas	3/24
peripheral nervous system	2/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	2/29
uterus	1/5

Expression Distribution

Surp
DRY EERY

mRNA 5-splice site recognition
alternative mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
negative regulation of RNA splicing
negative regulation of mRNA processing
mRNA splice site selection
mRNA cis splicing, via spliceosome
spliceosomal complex assembly
negative regulation of mRNA metabolic process
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
protein-containing complex assembly
RNA metabolic process
negative regulation of gene expression
protein-containing complex subunit organization
gene expression