SLC22A3

Entrez Summary: N/A
UniProt Summary: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.18
Apcin 25μM plus proTAME 2μM R04 exp177	-2.12
TGF-beta1 44ng/ml R08 exp528	-1.93
MLN-4924 0.2μM R00 exp21	-1.92
BI-D1870 2μM R04 exp162	-1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.76
RO-3306 3 to 4μM on day4 R04 exp165	-1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MFS 1
Sugar tr

histamine uptake
quaternary ammonium group transmembrane transporter activity
dopamine:sodium symporter activity
toxin transmembrane transporter activity
organic cation transmembrane transporter activity
dopamine uptake
histamine transport
catecholamine uptake
dopamine transport
quaternary ammonium group transport
catecholamine transport
azole transport
monoamine transport
regulation of appetite
neurotransmitter uptake
organic cation transport
toxin transport
ammonium transport
drug transmembrane transport
organic hydroxy compound transport
drug transport
neurotransmitter transport
regulation of neurotransmitter levels
response to nutrient levels
response to extracellular stimulus
import into cell
cation transport
response to drug
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport
membrane