SLC25A42

Entrez Summary: This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012].
UniProt Summary: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'- diphosphate. {ECO:0000269|PubMed:19429682}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adenosine 3,5-bisphosphate transmembrane transport
coenzyme A transmembrane transport
AMP transport
coenzyme A transmembrane transporter activity
AMP transmembrane transporter activity
ADP transmembrane transporter activity
coenzyme A transport
adenosine-diphosphatase activity
ATP transmembrane transporter activity
ADP transport
nucleotide transmembrane transport
coenzyme transport
purine-containing compound transmembrane transport
ATP transport
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
nucleotide transport
organic cation transport
cofactor transport
carbohydrate derivative transport
organophosphate ester transport
drug transport
nucleobase-containing compound transport
anion transmembrane transport
mitochondrial inner membrane
organic anion transport
anion transport
cation transport
ion transmembrane transport
response to drug
mitochondrion
transmembrane transport
ion transport
nitrogen compound transport