SLC35A3

Entrez Summary: This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
UniProt Summary: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides. {ECO:0000269|PubMed:10393322}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Nuc sug transp
UAA

UDP-N-acetylglucosamine transmembrane transporter activity
UDP-N-acetylglucosamine transmembrane transport
pyrimidine nucleotide-sugar transmembrane transport
nucleotide-sugar transmembrane transport
UDP-N-acetylglucosamine metabolic process
nucleotide-sugar metabolic process
amino sugar metabolic process
integral component of Golgi membrane
carbohydrate derivative transport
carbohydrate transport
nucleobase-containing compound transport
anion transmembrane transport
organic anion transport
nucleobase-containing small molecule metabolic process
anion transport
Golgi membrane
ion transmembrane transport
Golgi apparatus
carbohydrate derivative metabolic process
transmembrane transport
ion transport
small molecule metabolic process
nitrogen compound transport