SLC9C1

Entrez Summary: N/A
UniProt Summary: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Na H Exchanger
cNMP binding

potassium:proton antiporter activity
sodium:proton antiporter activity
sodium ion import across plasma membrane
ion channel activity
sperm motility
flagellated sperm motility
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
regulation of intracellular pH
sodium ion transmembrane transport
regulation of cellular pH
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
import across plasma membrane
regulation of pH
motile cilium
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
anion transmembrane transport
monovalent inorganic cation transport
spermatogenesis
inorganic cation transmembrane transport
male gamete generation
anion transport
cation transmembrane transport
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
gamete generation
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
multicellular organismal reproductive process