SMPD4

Entrez Summary: The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.65
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.92
Pyronaridine 1μM R06 exp295	-1.92
Colchicine 0.009μM R05 exp215	-1.81
MKC9989 10μM R03 exp133	-1.81
ZLN024 50μM R08 exp538	-1.75
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.73
Cytochalasin-B 5μM R07 exp349	1.76
Latrunculin-B 10μM R07 exp374	1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingomyelin phosphodiesterase D activity
sphingomyelin catabolic process
sphingomyelin phosphodiesterase activity
sphingomyelin metabolic process
glycerophospholipid catabolic process
sphingolipid catabolic process
phospholipid catabolic process
membrane lipid catabolic process
ceramide biosynthetic process
glycerolipid catabolic process
glycosphingolipid metabolic process
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
organophosphate catabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
trans-Golgi network
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
cellular response to tumor necrosis factor
response to tumor necrosis factor
lipid catabolic process
glycerophospholipid metabolic process
phospholipid metabolic process
in utero embryonic development
glycerolipid metabolic process
amide biosynthetic process
lipid biosynthetic process
Golgi membrane
chordate embryonic development
embryo development ending in birth or egg hatching
cellular amide metabolic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
embryo development
Golgi apparatus