SOST

Gene Information

Official Symbol: SOST
Official Name: sclerostin
Aliases and Previous Symbols: N/A
Entrez ID: 50964
UniProt: Q9BQB4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13337
Expression level (log2 read counts): -3.59

Expression Distribution

Screen	Score
Hydroxychloroquine 30μM R08 exp490	-1.75
Radicicol 0.16μM R05 exp242	-1.72
MS023 2μM R03 exp134	1.72
Nicotinamide Riboside 100μM R03 exp139	1.72

Sclerostin
DAN

cellular response to parathyroid hormone stimulus
response to parathyroid hormone
negative regulation of BMP signaling pathway
negative regulation of ossification
regulation of BMP signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of protein complex assembly
negative regulation of cellular response to growth factor stimulus
heparin binding
negative regulation of canonical Wnt signaling pathway
regulation of ossification
negative regulation of Wnt signaling pathway
response to mechanical stimulus
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ossification
regulation of cellular response to growth factor stimulus
regulation of canonical Wnt signaling pathway
transcription factor binding
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
collagen-containing extracellular matrix
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of protein complex assembly
protein-containing complex
cellular response to hormone stimulus
negative regulation of cellular component organization
response to hormone
regulation of cellular component biogenesis
Golgi apparatus
cell-cell signaling
response to abiotic stimulus
negative regulation of multicellular organismal process
cellular response to endogenous stimulus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
response to endogenous stimulus
positive regulation of transcription, DNA-templated
extracellular space