SOX12

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.35
BI-6727 0.0125μM R03 exp97	-1.98
AICAR 240μM R03 exp116	-1.75
Etoposide 10μM R00 exp20	-1.75
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.76
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.77
Trimetrexate 0.03μM R08 exp535	1.79
Tunicamycin 0.04μM R07 exp418	1.96
Ribavirin 10μM R01 exp52	2.01
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.07
Ammonium tetrathiomolybdate 10μM R08 exp448	2.15
RK-33 8μM R08 exp518	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear transcription factor complex
protein-DNA complex
transcription regulatory region sequence-specific DNA binding
spinal cord development
protein-DNA complex assembly
protein-DNA complex subunit organization
cell fate commitment
transcription coactivator activity
DNA-binding transcription activator activity, RNA polymerase II-specific
cellular protein-containing complex assembly
central nervous system development
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process